A three-day virtual conference will be held to discuss issues related to knowledge systems such as innovation spaces, digital resources, open-source software development, and education. The conference will address both the opportunities and challenges associated with these systems, including low costs of sharing and collaboration, as well as privacy, security, inequality, and biases. The conference will also explore the role of knowledge commons in addressing the consequences of COVID-19, which is considered the most serious global pandemic in over a century.